Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.38 |
| ▸ | KIT | P10721 | 4/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.36 |
| ▸ | ABL2 | P42684 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6336261 | 0.83 | FLT3 (0.46) | MEN1KMT2AFLT3CDK2CCNA1 | |
| SCHEMBL6336262 | 0.83 | FLT3 (0.46) | MEN1KMT2AFLT3CDK2CCNA1 | |
| SCHEMBL6498620 | 0.81 | KCNA5 (0.41) | MEN1KMT2AL3MBTL1KDM4ELMNA | |
| SCHEMBL6498617 | 0.81 | KCNA5 (0.41) | MEN1KMT2AL3MBTL1KDM4ELMNA | |
| SCHEMBL6502783 | 0.78 | CDK2 (0.46) | MEN1KMT2AFLT3CDK2CCNA1 | |
| SCHEMBL6496976 | 0.78 | ALDH1A1 (0.41) | MEN1KMT2ADRD2HTR2ADRD3 | |
| SCHEMBL6496972 | 0.78 | ALDH1A1 (0.41) | MEN1KMT2ADRD2HTR2ADRD3 | |
| SCHEMBL6332707 | 0.75 | KMT2A (0.43) | MEN1KMT2AFLT3CDK2CCNA1 | |
| SCHEMBL6332705 | 0.75 | KMT2A (0.43) | MEN1KMT2AFLT3CDK2CCNA1 | |
| SCHEMBL6336973 | 0.71 | CDK2 (0.41) | MEN1KMT2AFLT3CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | MEN1 4164/4885KMT2A 2331/4885FLT3 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.