Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PCK1 | P35558 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913043 | 0.90 | C5AR1 (0.42) | MAPTPCK1C5AR1TSSK1B | |
| SCHEMBL651033 | 0.90 | C5AR1 (0.44) | MAPTLMNAHTTC5AR1ALDH1A1 | |
| SCHEMBL650123 | 0.90 | C5AR1 (0.39) | MAPTLMNAHTTSMN1; SMN2C5AR1 | |
| SCHEMBL651956 | 0.89 | C5AR1 (0.43) | MAPTLMNAHTTSMN1; SMN2C5AR1 | |
| SCHEMBL1915992 | 0.88 | BCHE (0.42) | MAPTPCK1C5AR1TSSK1B | |
| SCHEMBL1913044 | 0.87 | RORC (0.46) | MAPTPCK1C5AR1TSSK1B | |
| SCHEMBL650580 | 0.87 | C5AR1 (0.41) | MAPTLMNAHTTC5AR1ALDH1A1 | |
| SCHEMBL5135971 | 0.87 | C5AR1 (0.41) | MAPTLMNAHTTSMN1; SMN2C5AR1 | |
| SCHEMBL652505 | 0.86 | C5AR1 (0.42) | MAPTLMNAHTTC5AR1ALDH1A1 | |
| SCHEMBL648790 | 0.86 | C5AR1 (0.43) | LMNAHTTC5AR1ALDH1A1DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |