Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986805 | 0.83 | NPC1 (0.59) | PDGFRBPDGFRACYP2A6PIK3CDPIK3CA | |
| SCHEMBL8637618 | 0.79 | GSTP1 (0.40) | CYP1A2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL2996550 | 0.78 | PDE10A (0.40) | CYP1A2CA12CA9ALDH1A1MAPT | |
| SCHEMBL32667946 | 0.78 | PDGFRB (0.77) | PDGFRBPDGFRACYP2A6BIRC5PIK3CD | |
| SCHEMBL2772360 | 0.78 | PDGFRB (0.77) | PDGFRBPDGFRACYP2A6BIRC5PIK3CD | |
| SCHEMBL16720404 | 0.75 | ADORA2A (0.43) | PDGFRBPDGFRAMAP4K4ALDH1A1MAPT | |
| SCHEMBL7873327 | 0.75 | PDGFRB (0.54) | PDGFRBPDGFRACYP2A6BIRC5PIK3CD | |
| SCHEMBL16720376 | 0.74 | NPC1 (0.50) | PDGFRBPDGFRACYP1A2ALDH1A1MAPT | |
| SCHEMBL12504960 | 0.72 | AR (0.51) | ALDH1A1MAPTNPC1RAB9AGLA | |
| SCHEMBL708999 | 0.72 | PDGFRB (0.75) | PDGFRBPDGFRACYP2A6BIRC5PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0797786-A4 | INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES | SOLA INT HOLDINGS (AU) | 1998-12-09 | — | — | EP | disclosed |
| EP-0797786-A1 | INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES | SOLA INTERNATIONAL HOLDINGS, LTD. (AU) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996018928-A1 | INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES | SOLA INTERNATIONAL HOLDINGS LTD. (AU) | 1996-06-20 | — | — | WO | disclosed |