Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | BCL2 | P10415 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | YAP1 | P46937 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617272 | 1.00 | REN (0.58) | RENATMMAOBBCL2PTPN1 | |
| SCHEMBL5888032 | 0.91 | ATM (0.58) | RENATMMAOBBCL2PTPN1 | |
| SCHEMBL2617274 | 0.91 | ATM (0.58) | RENATMMAOBBCL2PTPN1 | |
| SCHEMBL6896458 | 0.90 | ATM (0.67) | RENATMSYKRAB9AAPP | |
| SCHEMBL13770955 | 0.90 | ATM (0.67) | RENATMSYKRAB9AAPP | |
| SCHEMBL7239876 | 0.90 | ATM (0.67) | RENATMSYKRAB9AAPP | |
| SCHEMBL272406 | 0.88 | ATM (0.59) | RENATMBCL2PTPN1LTA4H | |
| SCHEMBL272806 | 0.88 | ATM (0.59) | RENATMBCL2PTPN1LTA4H | |
| SCHEMBL5410539 | 0.88 | ATM (0.59) | RENATMBCL2PTPN1LTA4H | |
| SCHEMBL12532787 | 0.87 | ATM (0.58) | RENATMBCL2PTPN1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |