Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | DRD4 | P21917 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CCR3 | P51677 | 1/20 | 0.60 |
| ▸ | TACR3 | P29371 | 7/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TACR2 | P21452 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631243 | 0.92 | POLB (0.64) | DRD2DRD4DRD3POLBTACR3 | |
| Hydrochloric Acid SCHEMBL9317938 | 0.91 | POLB (0.62) | DRD2DRD4DRD3POLBTACR3 | |
| SCHEMBL3907536 | 0.90 | POLB (0.60) | DRD2DRD4DRD3POLBCCR3 | |
| SCHEMBL6496917 | 0.89 | CCR8 (0.61) | DRD2DRD4DRD3POLBALDH1A1 | |
| SCHEMBL27679274 | 0.88 | POLB (0.58) | DRD2DRD4DRD3POLBTACR3 | |
| SCHEMBL3905302 | 0.87 | POLB (0.78) | DRD2DRD4DRD3POLBTACR3 | |
| SCHEMBL3911069 | 0.86 | TACR3 (0.55) | DRD2DRD4DRD3POLBCCR3 | |
| SCHEMBL19331129 | 0.85 | POLB (0.57) | DRD2DRD4DRD3POLBTACR3 | |
| SCHEMBL3911046 | 0.83 | POLB (0.61) | DRD2DRD4DRD3POLBALDH1A1 | |
| SCHEMBL6502713 | 0.82 | CCR8 (0.66) | DRD2DRD4DRD3POLBTACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | DRD2 3014/4885DRD4 3663/4885DRD3 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.