Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.40 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845815 | 0.85 | RECQL (0.45) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL10425119 | 0.80 | MAPT (0.45) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL1470131 | 0.79 | RECQL (0.50) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL9439994 | 0.79 | MAPT (0.44) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL11826827 | 0.77 | MAPT (0.42) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL5928954 | 0.76 | AKT1 (0.43) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL9040004 | 0.76 | AKT1 (0.43) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL814596 | 0.75 | RECQL (0.42) | RECQLMAPTALDH1A1LMNANPSR1 | |
| Hydrochloric Acid SCHEMBL11816675 | 0.74 | ALDH1A1 (0.40) | RECQLMAPTALDH1A1LMNANPSR1 | |
| SCHEMBL12484187 | 0.70 | RECQL (0.40) | RECQLMAPTALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906105-B2 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | BOWEN J PHILLIP (US) | 2005-06-14 | — | — | US | disclosed |