Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA3 | P07451 | 3/20 | 0.45 |
| ▸ | CA4 | P22748 | 3/20 | 0.45 |
| ▸ | CA6 | P23280 | 3/20 | 0.45 |
| ▸ | CA5A | P35218 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500670 | 1.00 | APP (0.48) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL692664 | 0.78 | KDM4E (0.50) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL692665 | 0.78 | KDM4E (0.50) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL6504545 | 0.78 | KIF11 (0.44) | APPKDM4EALDH1A1TSHRRAB9A | |
| SCHEMBL9518827 | 0.78 | APP (0.52) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL18530468 | 0.77 | NPSR1 (0.50) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL5219928 | 0.77 | HDAC1 (0.53) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL6499766 | 0.77 | ITGB2 (0.52) | APPKDM4EMAPK1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6821092 | 0.77 | KDM4E (0.49) | APPKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL6499764 | 0.77 | ITGB2 (0.52) | APPKDM4EMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |