Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.52 |
| ▸ | ITGAL | P20701 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA3 | P07451 | 3/20 | 0.49 |
| ▸ | CA4 | P22748 | 3/20 | 0.49 |
| ▸ | CA6 | P23280 | 3/20 | 0.49 |
| ▸ | CA5A | P35218 | 3/20 | 0.49 |
| ▸ | CA7 | P43166 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499766 | 1.00 | ITGB2 (0.52) | ITGB2ICAM1ITGALKDM4EMAPK1 | |
| SCHEMBL19508587 | 0.89 | HSD17B3 (0.54) | MAPK1ALDH1A1CA1CA2HPGD | |
| SCHEMBL13879637 | 0.81 | NPC1 (0.54) | ITGB2ICAM1ITGALALDH1A1APP | |
| SCHEMBL1124516 | 0.79 | PYGL (0.62) | ITGB2ICAM1ITGALKDM4EMAPK1 | |
| SCHEMBL7828903 | 0.79 | PYGL (0.62) | ITGB2ICAM1ITGALKDM4EMAPK1 | |
| SCHEMBL1124517 | 0.79 | PYGL (0.62) | ITGB2ICAM1ITGALKDM4EMAPK1 | |
| SCHEMBL13879640 | 0.79 | PYGL (0.62) | ITGB2ICAM1ITGALKDM4EALDH1A1 | |
| SCHEMBL7003267 | 0.78 | PKM (0.60) | ITGB2ICAM1ITGALKDM4EMAPK1 | |
| SCHEMBL7003269 | 0.78 | PKM (0.60) | ITGB2ICAM1ITGALKDM4EMAPK1 | |
| SCHEMBL13879635 | 0.78 | ALDH1A1 (0.56) | ITGB2ICAM1ITGALKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |