Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.32 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783846 | 1.00 | CRHR1 (0.41) | CRHR1MTNR1AMTNR1BMAOBGABRA1 | |
| SCHEMBL5783841 | 1.00 | CRHR1 (0.41) | CRHR1MTNR1AMTNR1BMAOBGABRA1 | |
| SCHEMBL5780328 | 0.92 | CRHR1 (0.43) | CRHR1MTNR1AMTNR1BGABRA1GABRB2 | |
| SCHEMBL5780326 | 0.92 | CRHR1 (0.43) | CRHR1MTNR1AMTNR1BGABRA1GABRB2 | |
| SCHEMBL6505605 | 0.92 | CRHR1 (0.43) | CRHR1MTNR1AMTNR1BGABRA1GABRB2 | |
| SCHEMBL5785473 | 0.92 | CRHR1 (0.42) | CRHR1POLB | |
| SCHEMBL6506650 | 0.92 | CRHR1 (0.42) | CRHR1POLB | |
| SCHEMBL5785470 | 0.92 | CRHR1 (0.42) | CRHR1POLB | |
| SCHEMBL6505939 | 0.90 | CRHR1 (0.40) | CRHR1POLBCDC7DBF4HTT | |
| SCHEMBL5782164 | 0.90 | CRHR1 (0.39) | CRHR1MTNR1AMTNR1BMAOBGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020601-A1 | Novel pyrazinones as CRF1 receptor antagonists | PFIZER INC | 2005-01-27 | — | — | US | claimed |
| US-20050020601-A1 | Novel pyrazinones as CRF1 receptor antagonists | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020601-A1 | Novel pyrazinones as CRF1 receptor antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885MTNR1A 136/4885MTNR1B 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.