Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437113 | 0.85 | KDM4E (0.71) | KDM4EGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL7799270 | 0.83 | KDM4E (0.69) | KDM4EGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL11246936 | 0.83 | MMP13 (0.64) | KDM4EGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL6546014 | 0.81 | PKM (0.68) | GAASMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL11354985 | 0.81 | KDM4E (0.67) | KDM4EGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL6359507 | 0.80 | KDM4E (0.65) | KDM4EGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL7952955 | 0.79 | KMT2A (0.69) | SMN1; SMN2NPC1KMT2AMEN1POLB | |
| SCHEMBL6506738 | 0.79 | KDM4E (0.58) | KDM4EGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5036685 | 0.79 | CA1 (0.66) | KDM4EGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL9637773 | 0.78 | KDM4E (0.63) | KDM4EGAASMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |