SCHEMBL6501337

SCHEMBL6501337

CCc1c(C)nc2ccccn2c1=O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.64
MAPT P10636 2/20 0.59
MAPK1 P28482 1/20 0.51
KDM4E B2RXH2 5/20 0.50
KMT2A Q03164 4/20 0.50
NPSR1 Q6W5P4 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
HSD17B10 Q99714 1/20 0.50
ACHE P22303 1/20 0.49
ALDH1A1 P00352 4/20 0.49
GAA P10253 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
GLA P06280 1/20 0.49
MEN1 O00255 2/20 0.48
HPGD P15428 2/20 0.48
KDM5B Q9UGL1 1/20 0.48
ADRA1A P35348 4/20 0.47
ADRA2A P08913 3/20 0.47
ADRA2B P18089 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11364801 0.98 ENPP2 (0.63) ENPP2MAPTMAPK1KDM4EKMT2A
SCHEMBL11352383 0.88 MAPT (0.64) ENPP2MAPTMAPK1KDM4EKMT2A
SCHEMBL6216602 0.86 MAPT (0.75) ENPP2MAPTMAPK1KDM4EKMT2A
Bromide SCHEMBL11357125 0.86 MAPT (0.63) ENPP2MAPTMAPK1KDM4EKMT2A
Hydrochloric Acid SCHEMBL11357339 0.86 MAPT (0.63) ENPP2MAPTMAPK1KDM4EKMT2A
Hydrochloric Acid SCHEMBL11369794 0.85 MAPT (0.73) ENPP2MAPTMAPK1KDM4EKMT2A
SCHEMBL2845694 0.85 MAPT (0.69) ENPP2MAPTMAPK1KDM4EKMT2A
SCHEMBL1444060 0.84 ENPP2 (0.65) ENPP2MAPTMAPK1KDM4EKMT2A
SCHEMBL11362274 0.84 MAPT (0.67) ENPP2MAPTMAPK1KDM4EKMT2A
Hydrochloric Acid SCHEMBL2049884 0.83 ENPP2 (0.64) ENPP2MAPTMAPK1KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6897308-B1 Process for the preparation of anti-psychotic 3-[2-[-4-(6-fluoro-1,2-benziosoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one RGP LIFE SCIENCES LIMITED (IN) 2005-05-24 US claimed
EP-1280804-B1 A PROCESS FOR THE PREPARATION OF ANTI-PSYCHOTIC 3- 2- 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO 1,2,-A]PYRIMIDIN-4-ONE RPG LIFE SCIENCES LTD (IN) 2004-04-14 EP claimed
EP-1280804-B1 A PROCESS FOR THE PREPARATION OF ANTI-PSYCHOTIC 3- 2- 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO 1,2,-A]PYRIMIDIN-4-ONE RPG LIFE SCIENCES LTD (IN) 2004-04-14 EP disclosed
EP-1280804-A1 A PROCESS FOR THE PREPARATION OF ANTI-PSCHOTIC 3- 2- 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO 1,2,-A]PYRIMIDIN-4-ONE RPG Life Sciences Limited (IN) 2003-02-05 EP disclosed
WO-2001085731-A1 A PROCESS FOR THE PREPARATION OF ANTI-PSCHOTIC 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2,-a]pyrimidin-4-one RPG LIFE SCIENCES LIMITED (IN) 2001-11-15 WO disclosed
EP-0672043-B1 NOVEL 4-(3-BENZOFURANYL)PIPERIDINYL AND 4-(3-BENZOTHIENYL)PIPERIDINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM JANSSEN PHARMACEUTICA NV (BE) 2001-05-30 EP disclosed
US-4291036-A Pyrido[1,2-A]pyrimidine derivatives and method of analgesic treatment CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1981-09-22 US disclosed
US-4219649-A ANALGESICS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) 1980-08-26 US disclosed