Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11362274 | 0.99 | MAPT (0.67) | MAPTENPP2ACHEADRA1AADRA2A | |
| Hydrochloric Acid SCHEMBL11357613 | 0.97 | MAPT (0.66) | MAPTENPP2ACHEADRA1AADRA2A | |
| SCHEMBL6216602 | 0.96 | MAPT (0.75) | MAPTENPP2ACHEADRA1AADRA2A | |
| Hydrochloric Acid SCHEMBL11369794 | 0.94 | MAPT (0.73) | MAPTENPP2ACHEADRA1AADRA2A | |
| SCHEMBL11352383 | 0.91 | MAPT (0.64) | MAPTENPP2ACHEADRA1AADRA2A | |
| Hydrochloric Acid SCHEMBL11357339 | 0.90 | MAPT (0.63) | MAPTENPP2ACHEADRA1AADRA2A | |
| Bromide SCHEMBL11357125 | 0.90 | MAPT (0.63) | MAPTENPP2ACHEADRA1AADRA2A | |
| SCHEMBL1444060 | 0.85 | ENPP2 (0.65) | MAPTENPP2ACHEADRA1AADRA2A | |
| SCHEMBL6501337 | 0.85 | ENPP2 (0.64) | MAPTENPP2ACHEADRA1AADRA2A | |
| SCHEMBL6491197 | 0.84 | ENPP2 (0.60) | MAPTENPP2ACHEADRA1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349846-B2 | Fused pyrimidine derivatives as TRPV3 modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2013-01-08 | — | — | US | disclosed |
| US-20100292254-A1 | Fused Pyrimidine Derivatives as Trpv3 Modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292254-A1 | Fused Pyrimidine Derivatives as Trpv3 Modulators | TRPV3, TRPV1, TRPV5 | MAPT 1674/4885ENPP2 1585/4885ACHE 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.