Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.68 |
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535353 | 0.85 | TSHR (0.50) | CYP19A1SLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL8463112 | 0.85 | SLC6A2 (0.55) | CYP19A1SLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL11538836 | 0.81 | CYP19A1 (1.00) | CYP19A1AKT1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2909600 | 0.79 | CYP19A1 (0.71) | CYP19A1AKT1GCGRFFAR2TSHR | |
| SCHEMBL11535640 | 0.78 | CYP19A1 (0.83) | CYP19A1AKT1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2124049 | 0.78 | IDO1 (0.56) | CYP19A1SLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL4076934 | 0.78 | SLC6A3 (0.68) | CYP19A1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL6505748 | 0.78 | CYP19A1 (0.68) | CYP19A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6508386 | 0.78 | SLC6A2 (0.45) | CYP19A1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL12204722 | 0.77 | CYP19A1 (0.68) | CYP19A1AKT1GCGRFFAR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043313-A1 | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043313-A1 | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade | TFPI, TFPI2, PLAT | CYP19A1 1130/4885AKT1 2315/4885SLC6A2 4848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.