Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508924 | 0.83 | ADORA1 (0.82) | MAPTADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL4829403 | 0.77 | ADORA1 (0.58) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL23969914 | 0.75 | ALDH1A1 (0.52) | AGTR1MAPTTDP1ADORA1ADORA3 | |
| SCHEMBL12496376 | 0.74 | ALDH1A1 (0.41) | MAPTADORA1MEN1ALDH1A1HPGD | |
| SCHEMBL28193696 | 0.74 | SLC2A1 (0.56) | SMN1; SMN2KDM4E | |
| SCHEMBL26523872 | 0.74 | TDP1 (1.00) | AGTR1MAPTTDP1ADORA1ADORA3 | |
| SCHEMBL2401750 | 0.74 | MAPT (1.00) | AGTR1MAPTTDP1ADORA1ADORA3 | |
| SCHEMBL6529699 | 0.73 | ADORA1 (0.74) | AGTR1MAPTTDP1ADORA1ADORA3 | |
| SCHEMBL15871200 | 0.72 | MAPT (0.62) | AGTR1MAPTTDP1ADORA1ADORA3 | |
| SCHEMBL49700 | 0.72 | ADORA2A (0.58) | ADORA1ADORA3ADORA2AADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033085-A1 | PYRIMIDINES DERIVATIVES AS ADENOSINE RECEPTORS LIGANDS | UNIVERSITEIT LEIDEN (NL) | 2005-04-14 | — | — | WO | claimed |
| WO-2005033085-A1 | PYRIMIDINES DERIVATIVES AS ADENOSINE RECEPTORS LIGANDS | UNIVERSITEIT LEIDEN (NL) | 2005-04-14 | — | — | WO | disclosed |