Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 16/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501838 | 0.77 | AGTR1 (0.58) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL13875704 | 0.77 | ADORA1 (0.58) | ADORA1ADORA3ADORA2AADORA2BABCG2 | |
| SCHEMBL24227649 | 0.77 | ADORA1 (0.63) | ADORA1ADORA3ADORA2AADORA2BABCG2 | |
| SCHEMBL4260774 | 0.76 | ADORA1 (0.77) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL438540 | 0.74 | MEN1 (0.75) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL4823120 | 0.73 | ADORA3 (1.00) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL24859012 | 0.73 | ADORA1 (0.94) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL4825271 | 0.73 | ADORA1 (1.00) | ADORA1ADORA3ADORA2AADORA2BMEN1 | |
| SCHEMBL28132404 | 0.73 | ADORA1 (0.53) | ADORA1ADORA3ADORA2AMEN1NTSR1 | |
| SCHEMBL17970040 | 0.72 | MEN1 (0.79) | ADORA1ADORA2AMEN1NTSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449470-B2 | Substituted pyrimidines as ligands of adenosine receptors | UNIVERSITEIT LEIDEN (NL) | 2008-11-11 | — | — | US | claimed |
| US-20070032510-A1 | Substituted pyrimidines as ligands of adenosine receptors | UNIVERSITEIT LEIDEN (NL) | 2007-02-08 | — | — | US | claimed |
| EP-1667985-A1 | SUBSTITUTED PYRIMIDINES AS LIGANDS OF ADENOSINE RECEPTORS | Universiteit Leiden (NL) | 2006-06-14 | — | — | EP | claimed |
| WO-2005033084-A1 | SUBSTITUTED PYRIMIDINES AS LIGANDS OF ADENOSINE RECEPTORS | UNIVERSITEIT LEIDEN (NL) | 2005-04-14 | — | — | WO | claimed |
| US-7449470-B2 | Substituted pyrimidines as ligands of adenosine receptors | UNIVERSITEIT LEIDEN (NL) | 2008-11-11 | — | — | US | disclosed |
| US-20070032510-A1 | Substituted pyrimidines as ligands of adenosine receptors | UNIVERSITEIT LEIDEN (NL) | 2007-02-08 | — | — | US | disclosed |
| EP-1667985-A1 | SUBSTITUTED PYRIMIDINES AS LIGANDS OF ADENOSINE RECEPTORS | Universiteit Leiden (NL) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005033084-A1 | SUBSTITUTED PYRIMIDINES AS LIGANDS OF ADENOSINE RECEPTORS | UNIVERSITEIT LEIDEN (NL) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032510-A1 | Substituted pyrimidines as ligands of adenosine receptors | ADORA2A, ADORA3, ADORA1 | ADORA1 3/4885ADORA3 2/4885ADORA2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.