Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6489394 | 0.98 | SIGMAR1 (0.63) | SIGMAR1GRIN2BHTR1ASLC18A3DRD2 | |
| SCHEMBL6075108 | 0.91 | SIGMAR1 (0.68) | SIGMAR1GRIN2BHTR1ASLC18A3DRD2 | |
| Hydrochloric Acid SCHEMBL6492780 | 0.90 | SIGMAR1 (0.67) | SIGMAR1GRIN2BHTR1ASLC18A3DRD2 | |
| SCHEMBL6081319 | 0.87 | SIGMAR1 (0.73) | SIGMAR1SLC18A3DRD2OPRL1KCNH2 | |
| SCHEMBL6492495 | 0.87 | SIGMAR1 (0.73) | SIGMAR1SLC18A3DRD2OPRL1KCNH2 | |
| SCHEMBL6493040 | 0.87 | SIGMAR1 (0.73) | SIGMAR1SLC18A3DRD2OPRL1KCNH2 | |
| SCHEMBL10268327 | 0.86 | SLC18A3 (0.61) | SIGMAR1GRIN2BSLC18A3DRD2OPRL1 | |
| Hydrochloric Acid SCHEMBL6489371 | 0.86 | SIGMAR1 (0.71) | SIGMAR1SLC18A3DRD2OPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL6491487 | 0.86 | SIGMAR1 (0.71) | SIGMAR1SLC18A3DRD2OPRL1KCNH2 | |
| Hydrochloric Acid SCHEMBL6489373 | 0.86 | SIGMAR1 (0.71) | SIGMAR1SLC18A3DRD2OPRL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040024218-A1 | Novel compounds | SMITHKLINE BEECHAM SPA | 2004-02-05 | — | — | US | claimed |
| EP-1129072-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | Smithkline Beecham S.p.A. (IT) | 2001-09-05 | — | — | EP | claimed |
| WO-2000027815-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | SMITHKLINE BEECHAM SPA (IT) | 2000-05-18 | — | — | WO | claimed |
| US-6969724-B2 | Compounds | SMITHKLINE BEECHAM-SPA (GB) | 2005-11-29 | — | — | US | disclosed |
| US-20040024218-A1 | Novel compounds | SMITHKLINE BEECHAM SPA | 2004-02-05 | — | — | US | disclosed |
| EP-1129072-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | Smithkline Beecham S.p.A. (IT) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027815-A2 | N-SUBSTITUTED AZACYCLES, THEIR PREPARATION AND THEIR USE AS ORL-1 RECEPTOR LIGANDS | SMITHKLINE BEECHAM SPA (IT) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024218-A1 | Novel compounds | OXER1, CLIC1, CCR1 | SIGMAR1 50/4885GRIN2B 1528/4885HTR1A 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.