Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP5K1C | O60331 | 17/20 | 0.83 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.83 |
| ▸ | PIP5K1B | O14986 | 4/20 | 0.78 |
| ▸ | PIP5K1A | Q99755 | 4/20 | 0.78 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.78 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.75 |
| ▸ | PI4KA | P42356 | 3/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.75 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.75 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500541 | 0.95 | PIP5K1C (0.82) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6503191 | 0.93 | PIP5K1C (0.80) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6505419 | 0.91 | PIP5K1C (0.81) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6501419 | 0.91 | PIP5K1C (1.00) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6504987 | 0.90 | PIP5K1C (1.00) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL1518720 | 0.88 | PIP5K1C (1.00) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6503198 | 0.88 | PIP5K1C (0.79) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6531186 | 0.87 | PIP5K1C (0.70) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6507850 | 0.87 | PIP5K1C (0.84) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 | |
| SCHEMBL6504356 | 0.87 | PIP5K1C (0.75) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005047236-A1 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| US-6673780-B2 | SUCH AS 4-(4-(3-HYDROXY-3-METHYL-BUTANE-1-SULFINYLMETHYL)-PHENYLMETHANESULFINYL)-2 -METHYL-BUTAN1-OL FOR TREATING AND PREVENTING CARDIOVASCULAR DISEASES, DYSLIPIDEMIAS, DYSPROTEINEMIAS, AND GLUCOSE METABOLISM DISORDERS | ESPERION THERAPEUTICS, INC. | 2004-01-06 | — | — | US | disclosed |
| EP-1366024-A2 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002030882-A9 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS INC (US) | 2003-02-20 | — | — | WO | disclosed |
| WO-2002030882-A2 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2002-04-18 | — | — | WO | disclosed |