Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP5K1C | O60331 | 15/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 11/20 | 1.00 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.88 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.88 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.88 |
| ▸ | PIP5K1B | O14986 | 3/20 | 0.88 |
| ▸ | PIP5K1A | Q99755 | 3/20 | 0.88 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.71 |
| ▸ | PI4KA | P42356 | 2/20 | 0.71 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.71 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.71 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.71 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518720 | 0.93 | PIP5K1C (1.00) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6502234 | 0.90 | PIP5K1C (0.83) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6503191 | 0.88 | PIP5K1C (0.80) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL1519003 | 0.88 | MAPK10 (1.00) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6501419 | 0.87 | PIP5K1C (1.00) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6505419 | 0.87 | PIP5K1C (0.81) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6503989 | 0.87 | PIP5K1C (0.76) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6504265 | 0.85 | PIP5K1C (0.80) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6500541 | 0.84 | PIP5K1C (0.82) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 | |
| SCHEMBL6503198 | 0.84 | PIP5K1C (0.79) | PIP5K1CPIK3CAMAPK10MAPK8MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |