Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.69 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074754 | 0.83 | IKBKB (0.61) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL4092875 | 0.81 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6505649 | 0.76 | IKBKB (0.45) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL5099661 | 0.76 | IKBKB (0.79) | IKBKB | |
| SCHEMBL6507152 | 0.75 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6505745 | 0.75 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL1382705 | 0.75 | IKBKB (0.69) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL5099737 | 0.74 | IKBKB (0.67) | IKBKB | |
| SCHEMBL5096797 | 0.74 | IKBKB (0.76) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL14204814 | 0.74 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |