Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.33 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506529 | 0.80 | KDM5A (0.36) | IKBKBCHEK1JAK2JAK3MEN1 | |
| SCHEMBL6512268 | 0.80 | IKBKB (0.35) | IKBKBCHEK1JAK2JAK3MEN1 | |
| SCHEMBL6514944 | 0.77 | KDM5A (0.37) | IKBKBCHEK1JAK2JAK3MEN1 | |
| SCHEMBL6503100 | 0.76 | IKBKB (0.69) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6506816 | 0.74 | CHEK1 (0.36) | IKBKBCHEK1 | |
| SCHEMBL6509499 | 0.68 | PTK2 (0.40) | MEN1KMT2A | |
| SCHEMBL6512326 | 0.67 | IKBKB (0.36) | IKBKBCHEK1JAK2JAK3MEN1 | |
| SCHEMBL6508772 | 0.66 | IKBKB (0.38) | IKBKBCHEK1JAK2JAK3MEN1 | |
| SCHEMBL4092875 | 0.63 | IKBKB (0.57) | IKBKBCHEK1JAK2JAK3MEN1 | |
| SCHEMBL6508526 | 0.61 | PTK2 (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |