Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926121 | 0.99 | GRM2 (0.31) | GRM2KDM4EGAAMAPTRAD52 | |
| Hydrochloric Acid SCHEMBL6096093 | 0.85 | KDM4E (0.33) | KDM4EGAAMAPTRAD52GFER | |
| Hydrochloric Acid SCHEMBL6503630 | 0.81 | SYK (0.33) | GRM2GFER | |
| SCHEMBL2929862 | 0.79 | SYK (0.34) | GRM2GFER | |
| Hydrochloric Acid SCHEMBL6097092 | 0.73 | KDM4E (0.31) | KDM4EGAAMAPTRAD52GFER | |
| SCHEMBL5850115 | 0.72 | GBA1 (0.37) | KDM4EGAAMAPTRAD52GFER | |
| SCHEMBL6602243 | 0.72 | KDM4E (0.32) | KDM4EGAAMAPTRAD52GFER | |
| Hydrochloric Acid SCHEMBL6494082 | 0.71 | MAPT (0.39) | GRM2KDM4EGAAMAPTRAD52 | |
| Hydrochloric Acid SCHEMBL6097578 | 0.70 | KDM4E (0.31) | KDM4EGAAMAPTRAD52GFER | |
| Hydrochloric Acid SCHEMBL6095935 | 0.70 | RAD52 (0.40) | KDM4EGAAMAPTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6923835-B2 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-08-02 | — | — | US | claimed |
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-07-01 | — | — | US | claimed |
| US-6923835-B2 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-08-02 | — | — | US | disclosed |
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CDC73 | GRM2 4773/4885KDM4E 532/4885GAA 4682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.