Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 8/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.49 |
| ▸ | ITGAL | P20701 | 8/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503201 | 1.00 | ITGB2 (0.49) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL6498627 | 0.92 | ITGB2 (0.51) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL8296927 | 0.92 | ITGB2 (0.51) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL6498635 | 0.92 | ITGB2 (0.51) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL6498794 | 0.87 | CAPN1 (0.49) | CAPN1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6498797 | 0.87 | CAPN1 (0.49) | CAPN1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6498757 | 0.84 | CAPN1 (0.47) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL6498751 | 0.84 | CAPN1 (0.47) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL6494761 | 0.80 | ITGB2 (0.53) | ITGB2ICAM1ITGALCAPN1ALDH1A1 | |
| SCHEMBL6494765 | 0.80 | ITGB2 (0.53) | ITGB2ICAM1ITGALCAPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |