Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 8/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 7/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503354 | 1.00 | ITGAL (0.44) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6503362 | 1.00 | ITGAL (0.44) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6500228 | 0.92 | ITGAL (0.46) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6500234 | 0.92 | ITGAL (0.46) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6495908 | 0.91 | ITGAL (0.51) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL8297366 | 0.91 | ITGAL (0.51) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6495913 | 0.91 | ITGAL (0.51) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6498508 | 0.90 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6498498 | 0.90 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1KMT2A | |
| SCHEMBL6498494 | 0.90 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |