Sugi Predict

Sugi Predict / Compounds / SCHEMBL6504039

SCHEMBL6504039

SCHEMBL6504039

COC(=O)NC(Cc1ccc(N)c2ccccc12)C(=O)OCC[Si](C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 4/20 0.42
▸ PTPN1 P18031 2/20 0.39
▸ MEN1 O00255 1/20 0.36
▸ HCRTR1 O43613 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ LNPEP Q9UIQ6 1/20 0.36
▸ ATM Q13315 1/20 0.36
▸ NMBR P28336 3/20 0.35
▸ FNTA P49354 1/20 0.35
▸ PGGT1B P53609 1/20 0.35
▸ CTSS P25774 1/20 0.35
▸ CTSK P43235 1/20 0.35
▸ ERAP2 Q6P179 1/20 0.34
▸ PPARG P37231 1/20 0.34
▸ PPARA Q07869 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6504000 0.83 TACR1 (0.39) TACR1PTPN1MEN1KMT2A
SCHEMBL6503580 0.80 CDC25B (0.47) TACR1PTPN1MEN1KMT2APPARG
SCHEMBL7065002 0.77 TACR1 (0.48) TACR1PTPN1MEN1HCRTR1KMT2A
SCHEMBL6495441 0.76 TACR1 (0.51) TACR1CTSSCTSKPPARGPPARA
SCHEMBL6494669 0.75 PTPN1 (0.55) TACR1PTPN1
SCHEMBL6494201 0.71 CTSS (0.54) TACR1PTPN1CTSSCTSKPPARG
SCHEMBL29466819 0.70 CTSL (0.61) TACR1ATMCTSSCTSK
SCHEMBL7059635 0.70 ERAP2 (0.48) TACR1PTPN1ERAP2
SCHEMBL28706022 0.69 NMBR (0.62) TACR1KMT2ANMBR
SCHEMBL29400092 0.69 NMBR (0.62) TACR1KMT2ANMBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6972340-B2 Selective protein tyrosine phosphatatase inhibitors ABBOTT LABORATORIES (US) 2005-12-06 — — US disclosed
WO-2003072537-A2 SELECTIVE PROTEIN TYROSINE PHOSPHATATASE INHIBITORS ABBOTT LABORATORIES (US) 2003-09-04 — — WO disclosed
EP-1313696-A2 AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS ABBOTT LABORATORIES (US) 2003-05-28 — — EP disclosed
WO-2003020688-A1 SELECTIVE PROTEIN TYROSINE PHOSPHATASE INHIBITORS ABBOTT LABORATORIES (US) 2003-03-13 — — WO disclosed
US-20020169157-A1 Selective protein tyrosine phosphatatase inhibitors ABBOTT LABORATORIES 2002-11-14 — — US disclosed
US-20020072516-A1 Selective protein tyrosine phosphatatase inhibitors ABBVIE INC. 2002-06-13 — — US disclosed
US-20020035137-A1 Amino (oxo) acetic acid protein tyrosine phosphatase inhibitors ABBOTT LABORATORIES 2002-03-21 — — US disclosed
WO-2002018323-A2 AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS ABBOTT LABORATORIES (US) 2002-03-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020035137-A1 Amino (oxo) acetic acid protein tyrosine phosphatase inhibitors PPM1A, PTPRO, PTP4A1 TACR1 2750/4885PTPN1 10/4885MEN1 3065/4885
US-20020169157-A1 Selective protein tyrosine phosphatatase inhibitors PPM1B, PPM1A, PPM1D TACR1 2748/4885PTPN1 10/4885MEN1 1392/4885
US-20020072516-A1 Selective protein tyrosine phosphatatase inhibitors PPM1B, PPM1A, PPM1D TACR1 2748/4885PTPN1 10/4885MEN1 1392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.