Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980590 | 0.80 | HDAC1 (0.68) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18221708 | 0.75 | SIGMAR1 (0.79) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6472763 | 0.75 | SIGMAR1 (0.52) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6925405 | 0.74 | SIGMAR1 (0.51) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6215204 | 0.72 | KCNH2 (0.59) | SIGMAR1ALDH1A1HTR2CDRD2HTR2A | |
| SCHEMBL13228108 | 0.71 | HDAC1 (0.61) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL326696 | 0.71 | SIGMAR1 (0.64) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL466954 | 0.71 | SIGMAR1 (1.00) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23289929 | 0.70 | HDAC1 (0.64) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13519235 | 0.70 | HDAC1 (0.69) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153998-A1 | Tetrahydroisoquinoline or isochroman compounds | ITO FUMITAKA (JP) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153998-A1 | Tetrahydroisoquinoline or isochroman compounds | OPRL1, NR1H3, HRH3 | SIGMAR1 11/4885TP53 4514/4885CYP1A2 570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.