Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10827257 | 0.85 | CYP3A4 (0.44) | MAPTTDP1HPGDL3MBTL1LMNA | |
| SCHEMBL11533162 | 0.84 | TDP1 (0.40) | MAPTTDP1HPGDL3MBTL1CYP3A4 | |
| SCHEMBL29703185 | 0.82 | CYP3A4 (0.54) | MAPTTDP1HPGDLMNACYP3A4 | |
| SCHEMBL166652 | 0.82 | CYP3A4 (0.54) | MAPTTDP1HPGDLMNACYP3A4 | |
| SCHEMBL3306947 | 0.81 | ALDH1A1 (0.47) | TDP1HPGDLMNACYP3A4TRPA1 | |
| SCHEMBL17027575 | 0.81 | MAPT (0.50) | MAPTTDP1HPGDL3MBTL1CYP3A4 | |
| SCHEMBL1428432 | 0.81 | TDP1 (0.56) | MAPTTDP1HPGDL3MBTL1LMNA | |
| SCHEMBL2157521 | 0.80 | CYP3A4 (0.43) | MAPTTDP1HPGDL3MBTL1LMNA | |
| SCHEMBL11660774 | 0.78 | MAPK1 (0.42) | MAPTTDP1HPGDLMNACYP3A4 | |
| SCHEMBL11648440 | 0.77 | ALDH1A1 (0.54) | MAPTTDP1HPGDL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |