Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505296 | 0.90 | EPHX2 (0.44) | CHEK1MAPK8SIGMAR1MAPK1GFER | |
| SCHEMBL6507350 | 0.81 | MAPK1 (0.43) | POLBCHEK1MAPK1GFERIKBKB | |
| SCHEMBL6507196 | 0.77 | MAPK1 (0.49) | CHEK1MAPK1GFERIKBKBMAPK10 | |
| SCHEMBL6530224 | 0.77 | MAPK1 (0.49) | CHEK1MAPK1GFERIKBKBMAPK10 | |
| Hydrochloric Acid SCHEMBL6506232 | 0.76 | MAPK1 (0.48) | CHEK1MAPK1GFERIKBKBMAPK10 | |
| SCHEMBL6510436 | 0.75 | MAPK1 (0.43) | POLBCHEK1MAPK1GFERIKBKB | |
| SCHEMBL6509035 | 0.73 | MAPK1 (0.48) | POLBCHEK1MAPK1GFERIKBKB | |
| SCHEMBL6510565 | 0.73 | MAPK8 (0.65) | MAPK8IKBKB | |
| SCHEMBL6507207 | 0.72 | MAPK1 (0.47) | POLBCHEK1MAPK1GFERIKBKB | |
| SCHEMBL6509261 | 0.71 | MAPK1 (0.49) | CHEK1MAPK1GFERIKBKBMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |