Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504760 | 0.90 | LMNA (0.52) | IKBKBCHEK1MAPK8MAPK1GFER | |
| SCHEMBL6507350 | 0.83 | MAPK1 (0.43) | IKBKBJAK2JAK3CHEK1MAPK1 | |
| SCHEMBL6507196 | 0.80 | MAPK1 (0.49) | IKBKBJAK2JAK3CHEK1MAPK1 | |
| SCHEMBL6530224 | 0.78 | MAPK1 (0.49) | IKBKBJAK2JAK3CHEK1MAPK1 | |
| Hydrochloric Acid SCHEMBL6506232 | 0.77 | MAPK1 (0.48) | IKBKBJAK2JAK3CHEK1MAPK1 | |
| SCHEMBL6510436 | 0.77 | MAPK1 (0.43) | IKBKBJAK2CHEK1MAPK1GFER | |
| SCHEMBL6509035 | 0.74 | MAPK1 (0.48) | IKBKBJAK2JAK3CHEK1MAPK1 | |
| SCHEMBL6507207 | 0.73 | MAPK1 (0.47) | IKBKBJAK2JAK3CHEK1MAPK1 | |
| SCHEMBL6503111 | 0.73 | MAPK8 (0.67) | IKBKBJAK2JAK3MAPK8MEN1 | |
| SCHEMBL6509261 | 0.73 | MAPK1 (0.49) | IKBKBJAK2JAK3CHEK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |