SCHEMBL6504770

SCHEMBL6504770

CC(=NOCc1ccc(F)cc1)C(C(=O)O)C(OS(=O)(=O)c1ccccc1)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPARG P37231 6/20 0.42
PPARA Q07869 6/20 0.42
CA12 O43570 2/20 0.39
ADAMTS4 O75173 1/20 0.36
S1PR1 P21453 1/20 0.36
GPR34 Q9UPC5 2/20 0.35
EGFR P00533 1/20 0.35
ERBB2 P04626 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
P2RX7 Q99572 2/20 0.34
MAOB P27338 1/20 0.34
FFAR1 O14842 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6508021 0.87 PPARG (0.43) PPARGPPARACA12ADAMTS4S1PR1
SCHEMBL6504759 0.78 PPARG (0.56) PPARGPPARAGPR34P2RX7
SCHEMBL6504765 0.78 PPARG (0.56) PPARGPPARAGPR34P2RX7
SCHEMBL6508014 0.69 PPARA (0.55) PPARGPPARAGPR34
SCHEMBL6508017 0.69 PPARA (0.55) PPARGPPARAGPR34
SCHEMBL6510008 0.68 PPARA (0.54) PPARGPPARA
SCHEMBL6510011 0.68 PPARA (0.54) PPARGPPARA
SCHEMBL6532444 0.66 PPARG (0.52) PPARGPPARA
SCHEMBL6511131 0.65 PPARG (0.59) PPARGPPARA
SCHEMBL776873 0.65 CA2 (0.47) CA12EGFRERBB2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005040127-A1 NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2005-05-06 WO claimed
WO-2005040127-A1 NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2005-05-06 WO disclosed