Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496629 | 0.87 | CRHR1 (0.41) | CRHR1DPP4 | |
| SCHEMBL6496771 | 0.85 | CRHR1 (0.40) | CRHR1DPP4 | |
| SCHEMBL6497952 | 0.80 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL6504824 | 0.80 | CRHR1 (0.41) | CRHR1DPP4 | |
| SCHEMBL6495413 | 0.76 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6495416 | 0.71 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL6497957 | 0.70 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6496775 | 0.69 | CRHR1 (0.41) | CRHR1DPP4 | |
| SCHEMBL6495917 | 0.67 | NPC1 (0.49) | CRHR1NPC1 | |
| SCHEMBL5804461 | 0.65 | NPC1 (0.50) | CRHR1NPC1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958341-B2 | Pyrazolopyrimidines as CRF antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-10-25 | — | — | US | disclosed |