Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.69 |
| ▸ | PPARG | P37231 | 14/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423680 | 0.84 | PPARA (0.51) | PPARAPPARGATMPPARDNR1H4 | |
| Muraglitazar SCHEMBL676469 | 0.81 | PPARA (1.00) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13722049 | 0.78 | PPARA (0.93) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL10184451 | 0.78 | PPARA (0.72) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13718146 | 0.78 | PPARA (0.93) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13721992 | 0.77 | PPARA (0.87) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13899395 | 0.77 | PPARA (0.63) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL6073227 | 0.76 | PPARA (0.90) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL10183853 | 0.76 | PPARA (0.64) | PPARAPPARGCYP2C9KCNH2PPARD | |
| SCHEMBL6073514 | 0.75 | PPARA (0.88) | PPARAPPARGCYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049589-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049589-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2005-06-02 | — | — | WO | disclosed |