Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | LGMN | Q99538 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922707 | 0.99 | GAA (0.39) | GAARAD52HRH3LGMNKCNH2 | |
| Hydrochloric Acid SCHEMBL6505708 | 0.86 | GAA (0.34) | GAARAD52 | |
| Hydrochloric Acid SCHEMBL2540311 | 0.85 | RAD52 (0.40) | GAARAD52HRH3LGMNKCNH2 | |
| Hydrochloric Acid SCHEMBL6328982 | 0.84 | RAD52 (0.40) | GAARAD52HRH3LGMNKCNH2 | |
| SCHEMBL2927862 | 0.84 | GAA (0.35) | GAARAD52 | |
| Hydrochloric Acid SCHEMBL6496555 | 0.84 | GAA (0.33) | GAARAD52 | |
| SCHEMBL2127393 | 0.84 | RAD52 (0.41) | GAARAD52HRH3LGMNKCNH2 | |
| Hydrochloric Acid SCHEMBL6505050 | 0.84 | MAPT (0.33) | GAARAD52 | |
| SCHEMBL2930250 | 0.83 | GAA (0.34) | GAARAD52 | |
| SCHEMBL2928431 | 0.83 | MAPT (0.33) | GAARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6923835-B2 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-08-02 | — | — | US | disclosed |