Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.32 |
| ▸ | LGMN | Q99538 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6328982 | 0.99 | RAD52 (0.40) | RAD52GAAHRH3LGMNKCNH2 | |
| SCHEMBL2127393 | 0.99 | RAD52 (0.41) | RAD52GAAHRH3LGMNKCNH2 | |
| Hydrochloric Acid SCHEMBL6505113 | 0.85 | GAA (0.38) | RAD52GAAHRH3LGMNKCNH2 | |
| SCHEMBL2922707 | 0.84 | GAA (0.39) | RAD52GAAHRH3LGMNKCNH2 | |
| Hydrochloric Acid SCHEMBL2537577 | 0.84 | MAPT (0.36) | RAD52GAAHRH3KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL6331452 | 0.84 | MAPT (0.36) | RAD52GAAHRH3KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL2127646 | 0.83 | GAA (0.31) | RAD52GAA | |
| Hydrochloric Acid SCHEMBL1154193 | 0.83 | MAPT (0.36) | RAD52GAAKDM4EMAPTTHRB | |
| SCHEMBL2126499 | 0.83 | MAPT (0.37) | RAD52GAAHRH3KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3069752 | 0.82 | GAA (0.34) | RAD52GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8043385-B2 | Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof | L'OREAL S.A. (FR) | 2011-10-25 | — | — | US | claimed |
| US-20100263138-A1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | L'OREAL S.A. (FR) | 2010-10-21 | — | — | US | claimed |
| EP-1428515-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a surfactant; methods and uses | OREAL (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1428514-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, a tertiary paraphenylenediamine and a benzomorpholine coupler; method and use | OREAL (FR) | 2007-09-19 | — | — | EP | claimed |
| US-7101406-B2 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | L'OREAL (FR) | 2006-09-05 | — | — | US | claimed |
| US-6946005-B2 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-09-20 | — | — | US | claimed |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | L'OREAL (FR) | 2004-12-16 | — | — | US | claimed |
| US-20040231067-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses | L'OREAL (FR) | 2004-11-25 | — | — | US | claimed |
| US-20040231068-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a cationic polymer, methods and uses | L'OREAL (FR) | 2004-11-25 | — | — | US | claimed |
| US-20040226109-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol, process therefor and use thereof | L'OREAL (FR) | 2004-11-18 | — | — | US | claimed |
| US-20040221399-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | L'OREAL (FR) | 2004-11-11 | — | — | US | claimed |
| US-20040216244-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and an organic diacid, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040216245-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a para-aminophenol, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040216246-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a polymer containing a fatty chain, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040216243-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a surfactant, processes therefor and uses thereof | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-28 | — | — | US | claimed |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| US-20040194227-A9 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-10-07 | — | — | US | claimed |
| US-20030229949-A1 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | SABELLE STEPHANE (FR) | 2003-12-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040231068-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a cationic polymer, methods and uses | PHOSPHO1, KRT18, NUP205 | RAD52 1196/4885GAA 3349/4885HRH3 276/4885 |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | CDC73, KRT18, PAH | RAD52 290/4885GAA 4851/4885HRH3 284/4885 |
| US-20040216246-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a polymer containing a fatty chain, methods and uses | KRT18, PLIN5, PLIN1 | RAD52 1041/4885GAA 4515/4885HRH3 285/4885 |
| US-20040216245-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a para-aminophenol, methods and uses | KRT18, CDC73, NUP205 | RAD52 143/4885GAA 4611/4885HRH3 343/4885 |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | KRT18, PPHLN1, PKLR | RAD52 1613/4885GAA 4341/4885HRH3 465/4885 |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | KRT18, CDC73, PPHLN1 | RAD52 457/4885GAA 4764/4885HRH3 526/4885 |
| US-20040221399-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a heterocyclic cationic direct dye, methods and uses | KRT18, CDC73, NUP205 | RAD52 481/4885GAA 4728/4885HRH3 149/4885 |
| US-20100263138-A1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | KRT18, TUBB3, VIM | RAD52 1604/4885GAA 4088/4885HRH3 2580/4885 |
| US-20040194227-A9 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CKAP4 | RAD52 651/4885GAA 4822/4885HRH3 824/4885 |
| US-20040216243-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a surfactant, processes therefor and uses thereof | KRT18, NOTUM, PHOSPHO1 | RAD52 2680/4885GAA 3878/4885HRH3 750/4885 |
| US-20040216244-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and an organic diacid, methods and uses | KRT18, CDC73, DDC | RAD52 293/4885GAA 4540/4885HRH3 762/4885 |
| US-20040226109-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol, process therefor and use thereof | FARSB, PARN, PKLR | RAD52 2081/4885GAA 1898/4885HRH3 711/4885 |
| US-20030229949-A1 | Pyrrolidinyl-substituted para-phenylenediamine derivatives substituted with a cationic radical, and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CKAP4 | RAD52 651/4885GAA 4822/4885HRH3 824/4885 |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | KRT18, PPHLN1, PYCR1 | RAD52 1134/4885GAA 4705/4885HRH3 474/4885 |
| US-20040231067-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses | KRT18, CDC73, PYCR1 | RAD52 357/4885GAA 4874/4885HRH3 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.