Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495325 | 0.87 | CRHR1 (0.41) | CRHR1MAPTTHRB | |
| SCHEMBL6507250 | 0.87 | CRHR1 (0.48) | CRHR1MAPTTHRB | |
| SCHEMBL6495691 | 0.81 | MAPT (0.47) | CRHR1MAPTTHRB | |
| SCHEMBL6505224 | 0.80 | CRHR1 (0.50) | CRHR1MAPTTHRB | |
| SCHEMBL6498692 | 0.78 | CRHR1 (0.43) | CRHR1MAPTTHRB | |
| SCHEMBL6494667 | 0.78 | MAPT (0.39) | CRHR1MAPTTHRB | |
| SCHEMBL6495917 | 0.77 | NPC1 (0.49) | CRHR1MAPT | |
| SCHEMBL6504878 | 0.76 | CRHR1 (0.49) | CRHR1MAPTTHRB | |
| SCHEMBL6504492 | 0.73 | MAPT (0.37) | CRHR1MAPTTHRB | |
| SCHEMBL7052095 | 0.72 | NPC1 (0.48) | CRHR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958341-B2 | Pyrazolopyrimidines as CRF antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-10-25 | — | — | US | claimed |
| US-6958341-B2 | Pyrazolopyrimidines as CRF antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-10-25 | — | — | US | disclosed |
| US-20030139426-A1 | Pyrazolopyrimidines as CRF antagonists | WILDE RICHARD G (US) | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139426-A1 | Pyrazolopyrimidines as CRF antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885MAPT 2933/4885THRB 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.