Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.88 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.88 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.70 |
| ▸ | PIP5K1C | O60331 | 12/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.67 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.63 |
| ▸ | PIP5K1B | O14986 | 3/20 | 0.63 |
| ▸ | PIP5K1A | Q99755 | 3/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.63 |
| ▸ | PI4KA | P42356 | 2/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.63 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.63 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518930 | 0.93 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL6037741 | 0.83 | MAPK10 (0.80) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL6037743 | 0.83 | MAPK10 (0.80) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518648 | 0.82 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518962 | 0.82 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL6504987 | 0.80 | PIP5K1C (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL12460810 | 0.79 | MAPK8 (0.67) | MAPK10MAPK8MAPK14 | |
| SCHEMBL6037742 | 0.79 | MAPK10 (0.71) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL6507708 | 0.78 | PIP5K1C (0.63) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL6037694 | 0.78 | MAPK10 (0.89) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |