Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.54 |
| ▸ | PPARA | Q07869 | 6/20 | 0.54 |
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | TSPO | P30536 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431844 | 0.86 | PPARG (0.44) | PPARGPPARASMPD1LMNANPSR1 | |
| SCHEMBL5423631 | 0.84 | SMN1; SMN2 (0.53) | PPARGPPARALMNANPSR1 | |
| SCHEMBL5440280 | 0.82 | PPARA (0.57) | PPARGPPARAPPARDSMPD1 | |
| SCHEMBL5441860 | 0.82 | PPARA (0.56) | PPARGPPARAPPARDTSPOSMPD1 | |
| SCHEMBL5427770 | 0.81 | SMPD1 (0.44) | PPARGPPARASMPD1BACE1TP53 | |
| SCHEMBL5432386 | 0.80 | POLB (0.51) | POLB | |
| SCHEMBL5441849 | 0.79 | RAB9A (0.50) | PPARGPOLBTP53 | |
| SCHEMBL5438445 | 0.79 | MAPT (0.46) | PPARGPOLB | |
| SCHEMBL5431889 | 0.79 | PGR (0.61) | PPARGPPARAPPARDLMNANPSR1 | |
| SCHEMBL5430265 | 0.79 | PPARA (0.35) | PPARGPPARAPPARDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049589-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049589-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2005-06-02 | — | — | WO | disclosed |