Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16990916 | 0.82 | CCR1 (0.47) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL30606304 | 0.77 | ALDH1A1 (0.58) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL12116515 | 0.77 | ALDH1A1 (0.58) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL2159909 | 0.77 | KDM4E (0.57) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL29870798 | 0.74 | KDM4E (0.77) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL15671504 | 0.74 | KDM4E (0.77) | KDM4ENPC1RAB9AMAPTATM | |
| SCHEMBL7864083 | 0.74 | HTT (0.44) | KDM4EALDH1A1HSD17B10CYP1A2SNCA | |
| SCHEMBL928439 | 0.74 | SNCA (0.55) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL256074 | 0.73 | SNCA (0.52) | SMN1; SMN2KDRSNCA | |
| SCHEMBL18667513 | 0.73 | KDM4E (0.52) | KDM4ENPC1RAB9AMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005075469-A1 | THIAZOLYL-HYDROXAMIC ACIDS AND THIADIAZOLYL-HYDROXAMIC ACIDS, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY | ARGENTA DISCOVERY LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005075469-A1 | THIAZOLYL-HYDROXAMIC ACIDS AND THIADIAZOLYL-HYDROXAMIC ACIDS, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY | ARGENTA DISCOVERY LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |