Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23214179 | 0.76 | TERT (0.52) | HTTRECQLTERTHDAC1HDAC8 | |
| SCHEMBL16640385 | 0.76 | HTT (0.56) | HTTRECQLCYP1A2KDM4EALDH1A1 | |
| SCHEMBL256074 | 0.75 | SNCA (0.52) | HDAC8SNCA | |
| SCHEMBL6505980 | 0.74 | KDM4E (0.57) | HTTCYP1A2KDM4EALDH1A1SNCA | |
| SCHEMBL7857587 | 0.72 | RAB9A (0.40) | HTTRECQLTERTCYP1A2KDM4E | |
| SCHEMBL30762091 | 0.72 | HTT (0.41) | HTTRECQLTERTHDAC1HDAC8 | |
| SCHEMBL15881584 | 0.72 | ALDH1A1 (0.43) | HTTRECQLHDAC1HDAC8HDAC6 | |
| SCHEMBL13801156 | 0.71 | HTT (0.59) | HTTRECQLTERTHDAC1HDAC8 | |
| SCHEMBL12571417 | 0.71 | ALDH1A1 (0.46) | HTTRECQLHDAC1HDAC8HDAC6 | |
| SCHEMBL78566 | 0.69 | NISCH (0.50) | HTTRECQLCYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1343215-A | 6-O-substituted macrolides with antibacterial activity | ABBOTT LAB (US) | 2002-04-03 | — | — | CN | disclosed |
| EP-1161438-A1 | 6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055168-A1 | 6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-09-21 | — | — | WO | disclosed |
| US-6054435-A | 6-O-substituted macrolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2000-04-25 | — | — | US | disclosed |