Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP5 | P51878 | 2/20 | 0.35 |
| ▸ | CASP4 | P49662 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293340 | 0.73 | SORD (0.60) | SORD | |
| SCHEMBL934301 | 0.72 | HRH4 (0.49) | ALDH1A1TSHRCASP1 | |
| SCHEMBL18390913 | 0.70 | GAA (0.47) | ALDH1A1 | |
| SCHEMBL1526838 | 0.69 | CHKA (0.39) | ALDH1A1TSHRMAPK1CASP1CASP5 | |
| SCHEMBL15415235 | 0.69 | CHKA (0.34) | SORDALDH1A1MAPK1 | |
| SCHEMBL26162997 | 0.69 | DRD2 (0.37) | DRD4DRD2DRD3RETTSHR | |
| SCHEMBL26162996 | 0.69 | HTT (0.39) | DRD4DRD2DRD3RETTSHR | |
| SCHEMBL7303410 | 0.68 | CYP1A2 (0.40) | ALDH1A1TSHRMAPK1POLB | |
| SCHEMBL15415674 | 0.68 | CYP1A2 (0.40) | ALDH1A1TSHRMAPK1POLB | |
| SCHEMBL6293201 | 0.67 | SORD (0.55) | SORD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020578-A1 | Sorbitol dehydrogenase inhibitors | PFIZER INC. | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020578-A1 | Sorbitol dehydrogenase inhibitors | SLC5A1, SORD, SLC5A2 | SORD 2/4885DRD4 1705/4885DRD2 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.