Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN6 | P29350 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 13/20 | 0.76 |
| ▸ | HTT | P42858 | 10/20 | 0.76 |
| ▸ | RAB9A | P51151 | 9/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.76 |
| ▸ | NPC1 | O15118 | 5/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.76 |
| ▸ | CDC25A | P30304 | 4/20 | 0.76 |
| ▸ | CDC25B | P30305 | 3/20 | 0.76 |
| ▸ | HK1 | P19367 | 1/20 | 0.76 |
| ▸ | CDC25C | P30307 | 1/20 | 0.76 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | ATM | Q13315 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.68 |
| ▸ | MITF | O75030 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31612179 | 1.00 | PTPN6 (1.00) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL6869616 | 0.83 | PTPN6 (0.70) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL12283174 | 0.81 | CDC25B (0.76) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL4868219 | 0.81 | MAPT (1.00) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL4873496 | 0.81 | MAPT (1.00) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL32664539 | 0.80 | MAPT (0.79) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL18457363 | 0.80 | PTPN6 (0.67) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL6506683 | 0.80 | MAPT (1.00) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL29633261 | 0.80 | MAPT (1.00) | PTPN6MAPTHTTRAB9ANPSR1 | |
| SCHEMBL21779251 | 0.79 | HSP90AA1 (0.76) | PTPN6MAPTHTTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240148676-A1 | COMBINATION THERAPY WITH PD-1 SIGNAL INHIBITOR | KYOTO UNIVERSITY (JP) | 2024-05-09 | — | — | US | claimed |
| EP-4299075-A1 | COMBINATION THERAPY WITH PD-1 SIGNAL INHIBITOR | Kyoto University (JP) | 2024-01-03 | — | — | EP | claimed |
| US-20240148676-A1 | COMBINATION THERAPY WITH PD-1 SIGNAL INHIBITOR | KYOTO UNIVERSITY (JP) | 2024-05-09 | — | — | US | disclosed |
| EP-4299075-A1 | COMBINATION THERAPY WITH PD-1 SIGNAL INHIBITOR | Kyoto University (JP) | 2024-01-03 | — | — | EP | disclosed |
| WO-2018231322-A1 | B CELL DISORDER CLASSIFICATION AND SUSCEPTIBITY TO INHIBITORS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-12-20 | — | — | WO | disclosed |
| US-9272993-B2 | Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2016-03-01 | — | — | US | disclosed |
| US-20140213627-A1 | NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2014-07-31 | — | — | US | disclosed |
| US-20050032794-A1 | Diamine derivatives of quinone and uses thereof | CLINICAL DATA, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213627-A1 | NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS | APP, PSEN1, PSEN2 | PTPN6 3755/4885MAPT 14/4885HTT 13/4885 |
| US-20050032794-A1 | Diamine derivatives of quinone and uses thereof | NQO1, DPYD, NQO2 | PTPN6 3397/4885MAPT 3849/4885HTT 3519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.