Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 1.00 |
| ▸ | HTT | P42858 | 9/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | ATM | Q13315 | 4/20 | 1.00 |
| ▸ | MITF | O75030 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | XBP1 | P17861 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.73 |
| ▸ | CDC25A | P30304 | 5/20 | 0.73 |
| ▸ | CDC25B | P30305 | 3/20 | 0.73 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.73 |
| ▸ | HK1 | P19367 | 1/20 | 0.73 |
| ▸ | CDC25C | P30307 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29633261 | 1.00 | MAPT (1.00) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL32664539 | 0.89 | MAPT (0.79) | MAPTHTTRAB9AKMT2ANPSR1 | |
| Dichlon SCHEMBL6439548 | 0.88 | MAPT (0.78) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL4868219 | 0.85 | MAPT (1.00) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL7240445 | 0.85 | MAPT (0.74) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL4873496 | 0.85 | MAPT (1.00) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL8663288 | 0.85 | MAPT (0.74) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL7912341 | 0.85 | MAPT (0.73) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL12283357 | 0.85 | MAPT (0.73) | MAPTHTTRAB9AKMT2ANPSR1 | |
| SCHEMBL2241314 | 0.84 | KMT2A (0.71) | MAPTHTTRAB9AKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748809-B | Method for synthesizing 2-substituted amino-1, 4-naphthoquinone derivative | 中国科学院成都有机化学有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-11084786-B2 | Compounds and pharmaceutical composition associated with ubiquitination-proteasome system | CALGENT BIOTECHNOLOGY CO., LTD. (TW) | 2021-08-10 | — | — | US | disclosed |
| US-20200385344-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM | CALGENT BIOTECHNOLOGY CO., LTD. (TW) | 2020-12-10 | — | — | US | disclosed |
| US-10745350-B2 | Compounds and pharmaceutical composition associated with ubiquitination-proteasome system | CALGENT BIOTECHNOLOGY CO., LTD. (TW) | 2020-08-18 | — | — | US | disclosed |
| US-20190144383-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM | CALGENT BIOTECHNOLOGY CO., LTD. (TW) | 2019-05-16 | — | — | US | disclosed |
| US-9272993-B2 | Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2016-03-01 | — | — | US | disclosed |
| US-9272993-B2 | Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of diseases involving amyloidogenesis | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2016-03-01 | — | — | US | disclosed |
| WO-2015172076-A1 | NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2015-11-12 | — | — | WO | disclosed |
| US-20140213627-A1 | NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2014-07-31 | — | — | US | disclosed |
| US-20140213627-A1 | NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2014-07-31 | — | — | US | disclosed |
| WO-2010026592-A1 | NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-03-11 | — | — | WO | disclosed |
| US-20070018155-A1 | New imidazole derivatives, preparation method thereof and organic electronic device using the same | LG CHEM. LTD. (KR) | 2007-01-25 | — | — | US | disclosed |
| US-20070018155-A1 | New imidazole derivatives, preparation method thereof and organic electronic device using the same | LG CHEM. LTD. (KR) | 2007-01-25 | — | — | US | disclosed |
| WO-2007011170-A1 | NEW IMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND ORGANIC ELECTRONIC DEVICE USING THE SAME | LG CHEM. LTD. (KR) | 2007-01-25 | — | — | WO | disclosed |
| US-20050032794-A1 | Diamine derivatives of quinone and uses thereof | CLINICAL DATA, INC. | 2005-02-10 | — | — | US | disclosed |
| WO-2004041840-A2 | PEPTIDE-BOUND CHROMOGENS USED FOR DETERMINING ENZYMATIC ACTIVITIES | C-CIT AG (CH) | 2004-05-21 | — | — | WO | disclosed |
| US-5807898-A | ASPIDIN, DESASPIDIN, METHYLENEBISASPIDINOL | KAPADIA GOVIND J (US) | 1998-09-15 | — | — | US | disclosed |
| US-5684035-A | NAPHTHOQUINONES | KAPADIA GOVIND J (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0071835-B1 | PROCESS FOR PREPARING URETHANES | BAYER AG (DE) | 1984-11-07 | — | — | EP | disclosed |
| EP-0071835-A1 | Process for preparing urethanes | BAYER AG (DE) | 1983-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144383-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM | PSMC1, PSME3, PSMB1 | MAPT 308/4885HTT 209/4885RAB9A 1884/4885 |
| US-10745350-B2 | Compounds and pharmaceutical composition associated with ubiquitination-proteasome system | PSMC1, PSME3, PSMB1 | MAPT 308/4885HTT 209/4885RAB9A 1884/4885 |
| US-20140213627-A1 | NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS | APP, PSEN1, PSEN2 | MAPT 14/4885HTT 13/4885RAB9A 2597/4885 |
| US-11084786-B2 | Compounds and pharmaceutical composition associated with ubiquitination-proteasome system | PSMC1, PSME3, PSMB1 | MAPT 308/4885HTT 209/4885RAB9A 1884/4885 |
| US-20070018155-A1 | New imidazole derivatives, preparation method thereof and organic electronic device using the same | ICMT, TIMM9, TIMM44 | MAPT 1131/4885HTT 1537/4885RAB9A 1722/4885 |
| US-20200385344-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITION ASSOCIATED WITH UBIQUITINATION-PROTEASOME SYSTEM | PSMC1, PSME3, PSMB1 | MAPT 308/4885HTT 209/4885RAB9A 1884/4885 |
| US-20050032794-A1 | Diamine derivatives of quinone and uses thereof | NQO1, DPYD, NQO2 | MAPT 3849/4885HTT 3519/4885RAB9A 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.