Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.45 |
| ▸ | TLR4 | O00206 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457452 | 0.85 | ADRB2 (0.53) | ADRB2DNM1ADRB3TLR4DRD2 | |
| SCHEMBL789339 | 0.85 | ADRB2 (0.63) | ADRB2DNM1ADRB3TLR4DRD2 | |
| SCHEMBL4608341 | 0.84 | ADRB2 (0.53) | ADRB2DNM1ADRB3TLR4DRD2 | |
| SCHEMBL9621537 | 0.83 | ADRB2 (0.55) | ADRB2DNM1ADRB3TLR4DRD2 | |
| SCHEMBL4727264 | 0.81 | ADRB2 (0.50) | ADRB2DNM1ADRB3TLR4DRD2 | |
| SCHEMBL5320295 | 0.80 | HTR1B (0.49) | ADRB2ADRB3KCNH2KDM4ESLC22A1 | |
| SCHEMBL7702692 | 0.79 | ADRB3 (0.67) | ADRB2DNM1ADRB3ADRB1 | |
| SCHEMBL4607220 | 0.79 | ADRB3 (0.48) | ADRB2DNM1ADRB3TLR4DRD2 | |
| SCHEMBL7701306 | 0.78 | ADRB3 (0.68) | ADRB2DNM1ADRB3ADRB1UTS2R | |
| SCHEMBL7438512 | 0.77 | ADRB2 (0.61) | ADRB2DNM1ADRB3TLR4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |