Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653927 | 1.00 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3CHRM4 | |
| SCHEMBL652472 | 0.85 | CHRNB2 (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL653686 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3CHRM4 | |
| SCHEMBL654093 | 0.78 | GPR119 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL651845 | 0.78 | GPR119 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3GPR119 | |
| SCHEMBL3583494 | 0.78 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CD | |
| SCHEMBL3582114 | 0.78 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CD | |
| SCHEMBL650660 | 0.77 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3579682 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3580869 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |