SCHEMBL6507641

SCHEMBL6507641

CCOCc1ccccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.57
LMNA P02545 1/20 0.48
PNMT P11086 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
SLC6A3 Q01959 1/20 0.46
MAOB P27338 2/20 0.45
MAOA P21397 1/20 0.45
TAAR1 Q96RJ0 3/20 0.44
MAPT P10636 3/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
NR4A2 P43354 1/20 0.42
AOC3 Q16853 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
ALDH1A1 P00352 2/20 0.41
TP53 P04637 1/20 0.40
GAA P10253 1/20 0.40
ALOX12 P18054 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3774965 0.86 IDO1 (0.67) IDO1LMNAPNMTMAOBMAOA
SCHEMBL648250 0.84 IDO1 (0.39) IDO1MAPTMEN1KMT2AALDH1A1
SCHEMBL9511260 0.83 IDO1 (0.60) IDO1LMNAPNMTTAAR1MAPT
SCHEMBL1988193 0.83 IDO1 (0.53) IDO1LMNAPNMTSLC6A2SLC6A4
SCHEMBL19055306 0.80 IDO1 (0.50) IDO1LMNAPNMTMAOBMAOA
SCHEMBL15771305 0.80 IDO1 (0.43) IDO1LMNAPNMTSLC6A2SLC6A4
SCHEMBL28089473 0.79 IDO1 (0.53) IDO1PNMTSLC6A2SLC6A4SLC6A3
SCHEMBL23222207 0.79 IDO1 (0.48) IDO1LMNAPNMTSLC6A2SLC6A4
1,2-Dichlorobenzene SCHEMBL3934904 0.79 TSHR (0.56) IDO1LMNAPNMTSLC6A2SLC6A4
SCHEMBL3149558 0.78 TSHR (0.35) IDO1LMNAMAPTALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0446301-B1 PREPARATION OF BIARYL COMPOUNDS EASTMAN CHEM CO (US) 1994-11-23 EP claimed
EP-0451201-A1 PREPARATION OF BIDENTATE LIGANDS EASTMAN KODAK COMPANY (US) 1991-10-16 EP claimed
EP-0446301-A1 PREPARATION OF BIARYL COMPOUNDS. EASTMAN KODAK CO (US) 1991-09-18 EP claimed
EP-0440737-A1 PREPARATION OF BIARYL COMPOUNDS EASTMAN KODAK COMPANY (US) 1991-08-14 EP claimed
EP-0376856-A1 Preparation of biaryl compounds EASTMAN KODAK COMPANY (US) 1990-07-04 EP claimed
WO-1990006930-A1 PREPARATION OF BIDENTATE LIGANDS EASTMAN KODAK COMPANY (US) 1990-06-28 WO claimed
EP-0375576-A1 Preparation of bidentate ligands EASTMAN KODAK COMPANY (US) 1990-06-27 EP claimed
WO-1990006295-A1 PREPARATION OF BIARYL COMPOUNDS EASTMAN KODAK COMPANY (US) 1990-06-14 WO claimed
WO-1990004577-A1 PREPARATION OF BIARYL COMPOUNDS EASTMAN KODAK COMPANY (US) 1990-05-03 WO claimed
EP-0366573-A1 Preparation of biaryl compounds EASTMAN CHEMICAL COMPANY (US) 1990-05-02 EP claimed
US-4912276-A Preparation of biaryl compounds EASTMAN KODAK COMPANY (US) 1990-03-27 US claimed
EP-4008717-A2 NOVEL INHIBITORS OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEINS Martin-Luther-Universität Halle-Wittenberg (DE) 2022-06-08 EP disclosed
EP-4008716-A1 NOVEL INHIBITORS OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEINS Martin-Luther-Universität Halle-Wittenberg (DE) 2022-06-08 EP disclosed
EP-3394056-B1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE SHY Therapeutics LLC (US) 2021-04-14 EP disclosed
US-10703959-B2 Functionalized silicate nanoparticle composition, removing and exfoliating asphaltenes with same BAKER HUGHES, A GE COMPANY, LLC (US) 2020-07-07 US disclosed
WO-1990006295-A1 PREPARATION OF BIARYL COMPOUNDS EASTMAN KODAK COMPANY (US) 1990-06-14 WO disclosed
WO-1990004577-A1 PREPARATION OF BIARYL COMPOUNDS EASTMAN KODAK COMPANY (US) 1990-05-03 WO disclosed
EP-0366573-A1 Preparation of biaryl compounds EASTMAN CHEMICAL COMPANY (US) 1990-05-02 EP disclosed
US-4916227-A From aromatic halide using coordinating catalyst containing nickel, phosphorus containing ligand, and reducing metal EASTMAN KODAK COMPANY (US) 1990-04-10 US disclosed
US-4912276-A Preparation of biaryl compounds EASTMAN KODAK COMPANY (US) 1990-03-27 US disclosed