Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 19/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL929816 | 0.82 | KIF11 (0.41) | KIF11DNMT1 | |
| SCHEMBL5528317 | 0.80 | CYP2C19 (0.42) | KIF11 | |
| SCHEMBL7729593 | 0.80 | PTPN1 (0.42) | KIF11DNMT1 | |
| SCHEMBL6363065 | 0.77 | CES2 (0.43) | KIF11 | |
| SCHEMBL22966169 | 0.76 | CYP1A2 (0.44) | KIF11DNMT1 | |
| SCHEMBL3188913 | 0.74 | CES2 (0.49) | KIF11 | |
| SCHEMBL8188401 | 0.73 | CHRM2 (0.47) | — | |
| SCHEMBL27415070 | 0.72 | KIF11 (0.45) | KIF11 | |
| Succinic Acid SCHEMBL7482968 | 0.72 | NR4A2 (0.45) | KIF11DNMT1 | |
| SCHEMBL4800015 | 0.70 | FFAR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953788-B1 | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-11 | — | — | US | disclosed |
| US-6770640-B1 | EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2004-08-03 | — | — | US | disclosed |
| CN-1150205-C | 3-mercaptoacetylamino-1,5-subsd. 2-oxo-azepon derivatives useful as inhibitor of metrix metalloproteinase | ���µ�˹ҩ�﹫˾ | 2004-05-19 | — | — | CN | disclosed |
| EP-0928291-B1 | 3-MERCAPTOACETYLAMINO-1,5-SUBSTITUTED-2-OXO-AZEPAN DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1150975-A1 | 1-CARBOXYMETHYL-2-OXO-AZEPAN DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000040577-A1 | 1-CARBOXYMETHYL-2-OXO-AZEPAN DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |
| EP-0751783-B1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC USE OF AMINOACETYLMERCAPTO DERIVATIVES | MERRELL PHARMA INC (US) | 2000-02-02 | — | — | EP | disclosed |
| CN-1234039-A | 3-mercaptoacetylamino-1, 5-disubstituted-2-oxo-azepane derivatives as matrix metalloproteinase inhibitors | HOECHST MARION ROUSSEL INC (US) | 1999-11-03 | — | — | CN | disclosed |
| EP-0928291-A1 | 3-MERCAPTOACETYLAMINO-1,5-SUBSTITUTED-2-OXO-AZEPAN DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEINASE | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-14 | — | — | EP | disclosed |
| EP-0625987-B1 | AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1998012211-A1 | 3-MERCAPTOACETYLAMINO-1,5-SUBSTITUTED-2-OXO-AZEPAN DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEINASE | HOECHST MARION ROUSSEL, INC. (US) | 1998-03-26 | — | — | WO | disclosed |
| US-5624921-A | Hypotriglyceridemic aminoacetylmercapto derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-04-29 | — | — | US | disclosed |
| US-5602122-A | Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylmercapto derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0751783-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC AMINOACETYLMERCAPTO DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| US-5529995-A | Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5488048-A | Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-30 | — | — | US | disclosed |
| WO-1995025532-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC AMINOACETYLMERCAPTO DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-09-28 | — | — | WO | disclosed |
| US-5424425-A | Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-13 | — | — | US | disclosed |
| EP-0625987-A1 | AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016103-A1 | AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | disclosed |