SCHEMBL6507828

SCHEMBL6507828

COCCCOc1ccc(C(=O)OC)cc1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
MGLL Q99685 1/20 0.52
KDM4E B2RXH2 3/20 0.51
KMT2A Q03164 1/20 0.51
TAS1R3 Q7RTX0 3/20 0.48
TAS1R1 Q7RTX1 3/20 0.48
HPGD P15428 1/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPT P10636 4/20 0.46
THRA P10827 1/20 0.46
THRB P10828 1/20 0.46
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46
HSP90AA1 P07900 1/20 0.45
HTT P42858 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
TP53 P04637 1/20 0.45
ALOX15 P16050 1/20 0.45
TTR P02766 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25314236 0.92 TDP1 (0.57) TDP1L3MBTL1MGLLKDM4EKMT2A
SCHEMBL9799085 0.88 TDP1 (0.52) TDP1L3MBTL1MGLLKDM4ETAS1R3
SCHEMBL12493216 0.88 ALDH1A1 (0.54) TDP1L3MBTL1MGLLKDM4ETAS1R3
SCHEMBL2934574 0.88 TDP1 (0.52) TDP1L3MBTL1MGLLKMT2AALDH1A1
SCHEMBL14926458 0.87 MGLL (0.64) TDP1L3MBTL1MGLLHPGDALDH1A1
SCHEMBL17991554 0.86 MGLL (0.56) TDP1L3MBTL1MGLLKDM4ETAS1R3
SCHEMBL12492829 0.86 ALDH1A1 (0.55) TDP1L3MBTL1MGLLKDM4ETAS1R3
SCHEMBL2585353 0.86 KDM4E (0.55) KDM4EKMT2AHPGDALDH1A1THRA
SCHEMBL15731867 0.85 MGLL (0.67) TDP1L3MBTL1MGLLHPGDALDH1A1
SCHEMBL14926460 0.85 MGLL (0.67) TDP1L3MBTL1MGLLHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082866-A2 SUBSTITUTED 1, 2, 4- TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS PFIZER LIMITED (GB) 2005-09-09 WO disclosed