Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxprenolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 12/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 12/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.72 |
| ▸ | HTR2B | P41595 | 4/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.72 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxprenolol SCHEMBL29698472 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL16311 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL29698462 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL17464297 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL16310 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL30209192 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL29935146 | 0.99 | ADRB2 (0.97) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL123517 | 0.99 | ADRB2 (0.97) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL628369 | 0.97 | ADRB2 (0.95) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 | |
| Oxprenolol SCHEMBL11334535 | 0.89 | ADRB2 (0.78) | ADRB2ADRB1CYP2D6CYP1A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675838-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | Puretecch LYT, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |