SCHEMBL6508441

SCHEMBL6508441

O=C(OCc1ccc(Cl)c(Cl)c1)C(CSc1ncccn1)C(O)c1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
NPSR1 Q6W5P4 1/20 0.44
MAPT P10636 3/20 0.44
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.44
HTT P42858 1/20 0.44
CYP51A1 Q16850 2/20 0.40
NPC1 O15118 5/20 0.39
RAB9A P51151 5/20 0.39
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
AGTR1 P30556 1/20 0.36
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
SCD O00767 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6308396 0.91 NPSR1 (0.47) MEN1KMT2ANPSR1MAPTALDH1A1
SCHEMBL3075097 0.85 MEN1 (0.40) MEN1KMT2ANPSR1MAPTALDH1A1
SCHEMBL3069083 0.82 KCNA5 (0.44) MAPTALDH1A1
SCHEMBL6309522 0.80 MAPT (0.38) MEN1KMT2ANPSR1MAPTALDH1A1
SCHEMBL3069248 0.77 CNR2 (0.37) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL6308945 0.74 LMNA (0.40) KMT2AALDH1A1LMNANPC1RAB9A
SCHEMBL6310041 0.74 LMNA (0.38) KMT2AMAPTALDH1A1LMNANPC1
SCHEMBL3066645 0.73 KCNA5 (0.43) NPSR1MAPT
SCHEMBL3061593 0.73 ADRB3 (0.36) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL3076912 0.73 FFAR1 (0.43) KMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005123727-A1 3-ARYL-3-HYDROXY- AND 3-ARYL-3-OXOPROPIONIC ACID ESTERS AS FUNGICIDES CROPSOLUTION, INC. (US) 2005-12-29 WO disclosed