Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652815 | 1.00 | LMNA (0.36) | LMNASMN1; SMN2OPRK1 | |
| SCHEMBL376559 | 0.86 | NR1H2 (0.30) | — | |
| SCHEMBL1438568 | 0.80 | LMNA (0.39) | LMNASMN1; SMN2 | |
| SCHEMBL22497045 | 0.80 | LMNA (0.39) | LMNASMN1; SMN2 | |
| SCHEMBL23130508 | 0.78 | LMNA (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL22441070 | 0.78 | LMNA (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL22441066 | 0.78 | LMNA (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL25257545 | 0.78 | LMNA (0.30) | LMNA | |
| SCHEMBL1437707 | 0.76 | LMNA (0.39) | LMNASMN1; SMN2OPRK1 | |
| SCHEMBL28350151 | 0.76 | LMNA (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |