Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650351 | 1.00 | GPR119 (0.51) | GPR119JAK2JAK1USP30NPC1 | |
| SCHEMBL929459 | 0.91 | GPR119 (0.54) | GPR119JAK2JAK1USP30NPC1 | |
| SCHEMBL1586797 | 0.91 | GPR119 (0.54) | GPR119JAK2JAK1USP30NPC1 | |
| SCHEMBL1586795 | 0.91 | GPR119 (0.54) | GPR119JAK2JAK1USP30NPC1 | |
| SCHEMBL8147886 | 0.87 | CYP2D6 (0.43) | HTTCCR5 | |
| SCHEMBL17228502 | 0.86 | GPR119 (0.48) | GPR119JAK2JAK1USP30NPC1 | |
| SCHEMBL29974053 | 0.85 | TSHR (0.49) | NPC1ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL653593 | 0.85 | TSHR (0.49) | NPC1ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL653594 | 0.85 | TSHR (0.49) | NPC1ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL7687290 | 0.84 | CCR5 (0.42) | ALDH1A1MAPK1HTTCCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |